By Wu, Guangyu
G protein-coupled receptors (GPCRs) constitute the largest superfamily of cellphone floor receptors that keep an eye on numerous phone services. during the last few a long time nice development has been made in defining the jobs of intracellular trafficking in controlling the performance of the receptors in addition to within the improvement of assorted human illnesses. This quantity of Progress in Molecular Biology and Translational Science reviews the hot realizing of GPCR trafficking regulators and molecular mechanisms.
- Written by means of destiny leaders within the discomfort field
- Covers quite a lot of targets
- Contains provocative principles approximately GPCR trafficking
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Additional resources for Trafficking of GPCRs
Dores MR, Trejo J. Atypical regulation of G protein-coupled receptor intracellular trafficking by ubiquitination. Curr Opin Cell Biol. 2014;27:44–50. 84. Piper RC, Katzmann DJ. Biogenesis and function of multivesicular bodies. Annu Rev Cell Dev Biol. 2007;23:519–547. 85. Gruenberg J, Stenmark H. The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol. 2004;5(4):317–323. 86. Dores MR, Chen B, Lin H, et al. ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting.
A possible explanation for this phenotype, however, is that the OS malformation after tunicamycin treatment was due to glycosylation deficiency in OS proteins other than rhodopsin. 34 Glycosylated proteins are recognized by chaperone proteins such as calnexin and calreticulin. Again consistent with the dispensable role of glycosylation for trafficking, rhodopsin does not Figure 2 Biogenesis of rhodopsin in the endoplasmic reticulum and formation of rhodopsin transport carriers in the Golgi. After folding in the ER, rhodopsin is transported to the Golgi where rhodopsin interacts with Arf4, FIP3, ASAP1, Rab8, and Rabbin8.
39 40 Ina Nemet et al. cover the molecular components assisting the biogenesis and the proper sorting. We will also review the confirmed binding and interacting partners that help target rhodopsin toward the connecting cilium as well as the cilia-localized components which direct proteins into the proper compartments of the OS. While rhodopsin is the most critical and abundant component of the photoreceptor OS, mutations in the rhodopsin gene commonly lead to its mislocalization within the photoreceptors.
Trafficking of GPCRs by Wu, Guangyu