By M.J. Jager, L. Desjardins, T. Kivelä, B.E. Damato, F. Bandello
Uveal cancer is an competitive kind of melanoma that could contain the iris, the ciliary physique, and/or the choroid, that's the most position of this tumor. sufferers frequently desire to be told approximately therapy offerings and the result of diversified techniques. very important present scientific questions are even if a biopsy will be taken of choroidal melanomas, what can be performed with this biopsy, and no matter if high-risk sufferers might be screened usually. This quantity describes the scientific features of uveal cancer in addition to different present innovations to be had for therapy, comparable to radioactive plaque therapy, proton beam remedy, and native tumor resection. in addition, ideas for taking biopsies and characterizing biopsy fabric are proven. destiny cures comparable to anti-VEGF therapy and ideas for the therapy of metastases also are mentioned. citizens with an curiosity in ocular oncology, ophthalmologists or physicians facing uveal cancer, in addition to sufferers wishing to understand extra approximately this malignancy will discover a topical replace on uveal cancer during this ebook.
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Additional info for Current Concepts in Uveal Melanoma (Developments in Ophthalmology)
31 Damato B, Patel I, Campbell IR, Mayles HM, Errington RD: Local tumor control after Ru-106 brachytherapy of choroidal melanoma. Int J Radiat Oncol Biol Phys 2005;63:385–391. 32 Kaiserman N, Kaiserman I, Hendler K, Frenkel S, Pe’er J: Ruthenium-106 plaque brachytherapy for thick posterior uveal melanomas. Br J Ophthalmol 2009;93:1167–1171. Pe’er 33 Tanandeh H, Chaudhry NA, Murray TG, Ehlies F, Hughes R, Scott IU, Markoe AM: Intraoperative echographic localization of iodine-125 episcleral plaque for brachytherapy of choroidal melanomas.
As for quality of life studies, these have tended to merge all patients into one cohort whereas it is likely that different age groups and sexes will each respond in a particular manner. Furthermore, quality of life is determined not only by the type of treatment that is administered but also whether or not such treatment is successful in conserving vision and preventing local recurrence. To my knowledge, patient-centred outcomes have not been reported according to these factors. For these reasons, in many patients, the selection of treatment for uveal melanoma is necessarily based on inadequate data.
This is because of the logistical difficulties preventing randomised studies of treatment versus non-treatment, enucleation versus conservative therapy, and of one type of conservative treatment versus another. The Collaborative Ocular Melanoma Study is widely regarded as confirming that iodine plaque radiotherapy is as effective as enucleation in prolonging life; however, the sample size, although impressive, was insufficient because many patients already had metastases at the time of treatment (as evidenced by their short survival times) and many others had a non-lethal tumour (as indicated by recent studies on genetic typing of uveal melanoma) .
Current Concepts in Uveal Melanoma (Developments in Ophthalmology) by M.J. Jager, L. Desjardins, T. Kivelä, B.E. Damato, F. Bandello