Conquering RAS. From Biology to Cancer Therapy by Asfar Azmi PDF

By Asfar Azmi

ISBN-10: 0128035056

ISBN-13: 9780128035054

ISBN-10: 0128035412

ISBN-13: 9780128035412

Conquering RAS: From Biology to melanoma Therapy offers introductory wisdom on how glossy RAS biology is taking form in gentle of more moderen technological improvement. each one bankruptcy is written in a fashion that emphasizes simplicity and clarity for either new investigators and verified researchers. whereas RAS biology has been intensively studied for greater than 3 a long time, we're but to determine any potent therapeutics that may intrude within the signaling cascade regulated by way of this grasp oncogene.

The publication covers subject matters starting from easy RAS biology, to translational biology and drug discovery functions. those issues should be beautiful to simple researchers operating in labs who search deeper realizing of the fashionable thoughts in RAS examine. at the different aspect, the oncologist on the patient’s bedside will locate the publication beneficial as they typically face the daunting activity of treating sufferers that predominantly have a affliction pushed by means of oncogenic KRAS.

  • Brings jointly large ranging themes in RAS simple and translational biology for the clinical and medical communities
  • Showcases contemporary developments in RAS learn below one entire volume
  • Includes videos, colour illustrations, and significant web site hyperlinks to facilitate a transparent realizing of RAS in melanoma research

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Extra resources for Conquering RAS. From Biology to Cancer Therapy

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JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. Cell Death Dis 2010;1:e29. [75] Genevet A, Tapon N. The Hippo pathway and apico-basal cell polarity. Biochem J 2011;436:213–24. [76] Yang S, Ji M, Zhang L, Chen Y, Wennmann DO, Kremerskothen J, et al. Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)-ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration. Cell Signal 2014;26:343–51. [77] Hilton HN, Stanford PM, Harris J, Oakes SR, Kaplan W, Daly RJ, et al.

Mol Carcinog 2007;46:865–71. [40] Grawenda AM, O’Neill E. Clinical utility of RASSF1A methylation in human malignancies. Br J Cancer 2015;113:372–81. [41] Vlahov N, Scrace S, Soto MS, Grawenda AM, Bradley L, Pankova D, et al. Alternate RASSF1 transcripts control SRC activity, E-cadherin contacts, and YAP-mediated invasion. Curr Biol 2015;25:3019–34. [42] Gregorieff A, Liu Y, Inanlou MR, Khomchuk Y, Wrana JL. Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.

Many of these downstream effectors are oncogenes or tumor suppressor genes in their own right, being directly mutated or silenced in cancers independent of Ras, eg, B-Raf, Pi3K, RalGDS, and RASSF1. The main downstream pathways activated Conquering RAS. 00002-3 Copyright © 2017 Elsevier Inc. All rights reserved. CONTENTS Introduction��������� 25 The Hippo Tumor Suppressor Pathway��������������� 27 MST and LATS as the Central Mammalian Kinases Under the Influence of Hippo Signaling������������� 28 YAP Signaling and Its Regulation by Hippo������������������� 32 Conclusions and Future Directions33 References���������� 34 25 26 CHAPTER 2: Ras and the Hippo Pathway in Cancer in these cases are mitogen-activated protein kinase (MAPK), Pi3K-AKT, and, of interest to this chapter, RASSF1-MST (Hippo), especially given the emerging cross talk of epidermal growth factor receptor (EGFR)-RAS signaling with the Hippo tumor suppressor pathway.

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Conquering RAS. From Biology to Cancer Therapy by Asfar Azmi


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