By Asfar Azmi
Conquering RAS: From Biology to melanoma Therapy offers introductory wisdom on how glossy RAS biology is taking form in gentle of more moderen technological improvement. each one bankruptcy is written in a fashion that emphasizes simplicity and clarity for either new investigators and verified researchers. whereas RAS biology has been intensively studied for greater than 3 a long time, we're but to determine any potent therapeutics that may intrude within the signaling cascade regulated by way of this grasp oncogene.
The publication covers subject matters starting from easy RAS biology, to translational biology and drug discovery functions. those issues should be beautiful to simple researchers operating in labs who search deeper realizing of the fashionable thoughts in RAS examine. at the different aspect, the oncologist on the patient’s bedside will locate the publication beneficial as they typically face the daunting activity of treating sufferers that predominantly have a affliction pushed by means of oncogenic KRAS.
- Brings jointly large ranging themes in RAS simple and translational biology for the clinical and medical communities
- Showcases contemporary developments in RAS learn below one entire volume
- Includes videos, colour illustrations, and significant web site hyperlinks to facilitate a transparent realizing of RAS in melanoma research
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Extra resources for Conquering RAS. From Biology to Cancer Therapy
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Many of these downstream effectors are oncogenes or tumor suppressor genes in their own right, being directly mutated or silenced in cancers independent of Ras, eg, B-Raf, Pi3K, RalGDS, and RASSF1. The main downstream pathways activated Conquering RAS. 00002-3 Copyright © 2017 Elsevier Inc. All rights reserved. CONTENTS Introduction��������� 25 The Hippo Tumor Suppressor Pathway��������������� 27 MST and LATS as the Central Mammalian Kinases Under the Influence of Hippo Signaling������������� 28 YAP Signaling and Its Regulation by Hippo������������������� 32 Conclusions and Future Directions33 References���������� 34 25 26 CHAPTER 2: Ras and the Hippo Pathway in Cancer in these cases are mitogen-activated protein kinase (MAPK), Pi3K-AKT, and, of interest to this chapter, RASSF1-MST (Hippo), especially given the emerging cross talk of epidermal growth factor receptor (EGFR)-RAS signaling with the Hippo tumor suppressor pathway.
Conquering RAS. From Biology to Cancer Therapy by Asfar Azmi