New PDF release: Computational Methods in Synthetic Biology

By Mario Andrea Marchisio

ISBN-10: 149391877X

ISBN-13: 9781493918775

ISBN-10: 1493918788

ISBN-13: 9781493918782

This quantity offers entire insurance of the computational ways presently utilized in man made Biology. Chapters concentrate on computational equipment and algorithms for the layout of bio-components, perception on CAD courses, research ideas, and dispensed structures. Written within the hugely winning Methods in Molecular Biology sequence layout, the chapters comprise the type of designated description and implementation suggestion that's the most important for purchasing optimum ends up in the laboratory.

Authoritative and functional, Computational equipment in artificial Biology serves as a consultant to devise in silico the in vivo or in vitro building of quite a few artificial bio-circuits.

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Andersen ES (2010) Prediction and design of DNA and RNA structures. N Biotechnol 27 (3):184–193 17. Douglas SM et al (2009) Rapid prototyping of 3D DNA-origami shapes with caDNAno. Nucleic Acids Res 37(15):5001–5006 18. Williams S et al (2009) Tiamat: a threedimensional editing tool for complex DNA structures. In: Goel A, Simmel F, Sosı´k P (eds) DNA computing. Springer, Berlin, pp 90–101 19. Zhu J et al (2009) UNIQUIMER 3D, a software system for structural DNA nanotechnology design, analysis and evaluation.

1b). 50 -OH-terminated RNA is degraded in an RppHindependent (RppHÀ) mechanism that is characteristically slower Fig. 1 Ribozyme- and aptazyme-regulated expression devices (rREDs and aREDs). In this chapter, rREDs are designed to program static levels of quantitatively predictable genetic expression in E. coli, as in [5]. (a) Static rRED and dynamic ligand-controlled aRED schematic in SBOL format. (b) Schematic of the underlying rRED and aRED genetic control mechanism Computational RNA Transcript Design 47 than the rate with which the 50 PPP-terminated mRNA is degraded by RppH-dependent (RppH+) pathways.

Han D et al (2013) DNA gridiron nanostructures based on four-arm junctions. Science 339 (6126):1412–1415 13. Han D et al (2013) Unidirectional scaffoldstrand arrangement in DNA origami. Angew Chem Int Ed Engl 52(34):9031–9034 14. Wei B, Dai M, Yin P (2012) Complex shapes self-assembled from single-stranded DNA tiles. Nature 485(7400):623–626 15. Ke Y et al (2012) Three-dimensional structures self-assembled from DNA bricks. Science 338 (6111):1177–1183 16. Andersen ES (2010) Prediction and design of DNA and RNA structures.

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Computational Methods in Synthetic Biology by Mario Andrea Marchisio

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