Get Comparative Genomics: Basic and Applied Research PDF

By James R. Brown

ISBN-10: 0849392160

ISBN-13: 9780849392160

Whilst genomic study first got here at the scene, a lot of the biomedical study group considered it as a restricted enterprise with constrained strength. We now be aware of that such an review used to be either hugely untimely and beautifully erroneous. within the final ten years, we’ve witnessed such extraordinary acceleration within the merger of uncomplicated and utilized genomic study that, between different issues, genomic examine is now considered being intrinsic to present drug examine. via rigorous comparative research, the genomes of cold-blooded vertebrate, avian, and different mammalian species are offering a deeper knowing of the human genome. additionally, genomic sequences, that are changing into to be had for numerous species have confirmed to be hugely appropriate to drug study with reference to a couple of differently intractable stipulations.

Rather than supplying a complete quantity overlaying each element of comparative genomics, Comparative Genomics: simple and utilized study embodies the varied pursuits of widespread researchers within the box. Compiling first hand descriptions in their pioneering paintings, the textual content specializes in commonalities and synergies around the wide box of comparative genomics. between its many subject matters it covers—

·         innovative advances in DNA-sequencing expertise

·         daring new ways to the association and research of huge phylogenetic information units

·         The impression of comparative genomics on our figuring out of evolution

·         Efforts towards constructing novel antimicrobial medications, by utilizing bacterial pathogen genomes

Ultimately, destiny breakthroughs in comparative genomics will rely on the ongoing interplay and interdependency of utilized and uncomplicated study. This seminal quantity demonstrates either the ability and the culmination of that cooperation, and in doing so defines and lays the foundation for persisted development.

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Extra resources for Comparative Genomics: Basic and Applied Research

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Lett. 6, 489–492 (2004). 67. Gourlain, T. et al. Enhancing the catalytic repertoire of nucleic acids. II. Simultaneous incorporation of amino and imidazolyl functionalities by two modified triphosphates during PCR. Nucleic Acids Res. 29, 1898–1905 (2001). 68. Southworth, M. , Kucera, R. , Jannasch, H. W. & Perler, F. B. Cloning of thermostable DNA polymerases from hyperthermophilic marine Archaea with emphasis on Thermococcus sp. 9 degrees N-7 and mutations affecting 3`-5` exonuclease activity.

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13. Illumina Inc. Illumina signs definitive agreement to acquire Solexa. http://investor. c=121127andp=irol-newsArticleandID=929959andhi ghlight= (2006). 14. , Swerdlow, H. & Milton, J. Labelled nucleotides. S. patent 7,057,026 B2, 2006. 15. , Kartalov, E. & Quake, S. R. Sequence information can be obtained from single DNA molecules. Proc. Natl. Acad. Sci. U. S. A. 100, 3960–3964 (2003). 16. Ju, J. et al. Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators.

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Comparative Genomics: Basic and Applied Research by James R. Brown

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