Download e-book for kindle: Cardiology of the Horse 2nd edition by Celia Marr BVMS MVM PhD MRCVS, Mark Bowen BVetMed PhD

By Celia Marr BVMS MVM PhD MRCVS, Mark Bowen BVetMed PhD CertEM(IntMed) MRCVS

ISBN-10: 0702028177

ISBN-13: 9780702028175

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Extra resources for Cardiology of the Horse 2nd edition

Example text

Equine Vet J 2002; 34(4):411–416. Vaughan Williams EM. Adrenergic arrhythmogenicity. In: Vaughan Williams EM, editor. Antiarrhythmic Drugs. Handbook of Experimental Pharmacology. vol 89. Berlin: Springer Verlag; 1990. p. 303–308. Toneke K. Beta-adrenoceptors in equine trachea and heart. Vet Res Commun 1999;23(1):41–51. Brodde OE. β1 and β2adrenoceptors in the human heart: properties, function and alterations in chronic heart failure. Pharmacol Rev 1991;43:203–242. Kiriazis H, Wang K, Xu Q, et al.

Under normal circumstances, production of NO by endothelial cells is not limited by supply of substrate. Endothelium-derived NO (EDNO) permeates biological membranes without hindrance and enters adjacent vascular smooth muscle cells, binding to the haem iron of the soluble enzyme, guanylate cyclase (GC). 6 Important vasoactive mediators released by the endothelium VASODILATORS VASOCONSTRICTORS Nitric oxide Endothelin (peptide) Prostacyclin Arachidonic acid metabolites Endothelium-dependent hyperpolarizing factor (chemical nature unknown) A diffusible factor released from hypoxic endothelial cells (unidentified) 28 Structural analogues of l-arginine, such as NG monomethyl-l-arginine, which inhibit production of EDNO by competing with l-arginine for the eNOS enzyme, cause a rise in total peripheral resistance and arterial blood pressure in vivo in most species examined.

48. 49. 50. 51. 52. 53. 54. 55. (ELITE II). Am Heart J 2005; 150(1):123–131. Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999;341(10):709–717. Mill JG, Milanez Mda C, de Resende MM, Gomes Mda G, Leite CM. Spironolactone prevents cardiac collagen proliferation after myocardial infarction in rats. Clin Exp Pharmacol Physiol 2003; 30(10):739–744.

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Cardiology of the Horse 2nd edition by Celia Marr BVMS MVM PhD MRCVS, Mark Bowen BVetMed PhD CertEM(IntMed) MRCVS

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