Download e-book for kindle: Cardiac Drug Development Guide (Methods in Pharmacology and by Michael K. Pugsley

By Michael K. Pugsley

ISBN-10: 1588290972

ISBN-13: 9781588290977

ISBN-10: 1592594042

ISBN-13: 9781592594047

Cardiac Drug improvement advisor outlines, intimately, the therapeutics of cardiac drugs at present on the leading edge of medical study and improvement around the globe. This quantity integrates uncomplicated and medical cardiac pharmacology through c- bining, for the 1st time, either classical and molecular features of healing drug improvement. The chapters include a large spectrum of healing parts and as a result contain a entire dialogue of molecular, biochemical, and electrophy- ological options in accordance with years of in vitro in addition to in vivo pharmacological st- ies. furthermore, the latter a part of the booklet contains accomplished scientific cardiac chapters that describe very important subject matters in molecular drugs. those chapters additionally talk about present medical healing developments in medication and supply an review of the efficacy of novel medications in those components. Cardiac Drug improvement consultant has many designated and striking gains that set it except different cardiac pharmacology books. This ebook introduces subject matters in an simply comprehensible layout for researchers in lots of various disciplines by way of integrating and thereby simplifying suggestions now not frequently mentioned throughout a large variety of cardiac disciplines and in a hugely technical box. each one bankruptcy not just introduces and describes the body structure, pharmacology, and pathophysiology of the disorder, but additionally overviews the medical implications of drug improvement, what levels those components are at the moment in, and in addition studies a number of the methodologies considering drug discovery and improvement. for this reason, this publication presents a entire assessment of the main complicated methods in cardiac pharmacology this present day.

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Additional resources for Cardiac Drug Development Guide (Methods in Pharmacology and Toxicology)

Example text

7. Irisawa, H. and Noma, A. (1984) Pacemaker currents in mammalian nodal cells. J. Mol. Cell Cardiol. 16, 777–781. 8. Maylie, J. and Morad, M. (1984) Ionic currents responsible for the generation of pacemaker current in the rabbit sino-atrial node. J. Physiol. 355, 215–235. 9. Bader, C. , Macleish, P. , and Schwartz, E. A. (1979) A voltage-clamp study of the light response in solitary rods of the tiger salamander. J. Physiol. 296, 1–26. 10. DiFrancesco, D. (1993). Pacemaker mechanisms in cardiac tissue.

1996) Structure and function of cyclic nucleotidegated channels. Annu. Rev. Neurosci. 19, 235–263. 48. Wainger, B. , Siegelbaum, S. , and Tibbs, G. R. (2001) Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature 411, 805–810. 49. , and Biel, M. (1999) Two pacemaker channels from human heart with profoundly different activation kinetics. EMBO J. 18, 2323–2329. 50. , Shumyatsky, G. , Tibbs, G. , et al. (2000) Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS.

1463, 1–19. 31. , and Bois, P. (2000) Thyroid hormone increases the conductance density of f-channels in rabbit sino-atrial node cells. Receptors Channels 7, 1–8. 32. , Liu, Y. , Cohen, I. , et al. (1997) Positive chronotropic actions of parathyroid hormone and parathyroid hormone-related peptide are associated with increases in the current, I(f), and the slope of the pacemaker potential. Circulation 96, 3704–3709. 33. DiFrancesco, D. and Tromba, C. (1988) Inhibition of the hyperpolarization-activated current (if) induced by acetylcholine in rabbit sino-atrial node myocytes.

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Cardiac Drug Development Guide (Methods in Pharmacology and Toxicology) by Michael K. Pugsley

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