Download e-book for kindle: Burger's Medicinal Chemistry and Drug Discovery, by Donald A. Abraham

By Donald A. Abraham

ISBN-10: 0471370290

ISBN-13: 9780471370291

His is quantity three: Cardiovascular brokers and Endocrines, of Burger's Medicinal Chemistry and Drug Discovery, sixth variation. This new quantity comprises serious new chapters on Endogenous Vasoactive Peptides, Iron Chelators and healing makes use of, and basics of Steroid Chemistry and Biochemistry.

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Extra info for Burger's Medicinal Chemistry and Drug Discovery, Cardiovascular Agents and Endocrines

Sample text

Therefore, these compounds are also named as digitalis, digoxin, and digitoxin. Currently, digoxin is the only cardiac glycoside commercially available in United States. Glycosides have a characteristic steroid (aglycone) structure complexed with a sugar moiety at C-3 position of the steroid through the p-hydroxyl group. Glycosides are mainly used in the prophylactic management and treatment of congestive heart failure and atrial fibrillation. They are known to relieve the symptoms of systemic venous congestion (right-sided heart failure or peripheral edema) and pulmonary congestion (left-sided heart failure).

Felodipine can lead to increased excretion of potassium, magnesium, and calcium (148). It has been recommended that to prevent side effects, individuals who are taking felodipine should avoid grapefruit and its juice (149). This is because grapefruit (juice) is an inhibitor of cytochrome P450 isoforms 3A4 and 1A2, which are needed for the normal metabolism of felodipine. Isradipine (25) (Fig. 3): Isradipine is a calcium antagonist that is available for oral administration and is used in the management of hypertension, either alone or concurrently with thiazide-type diuretics (150153).

Propranolol(47) is the prototype agent for this class of compounds. Because of the substitution pattern on its aromatic ring, it is not a selective P-adrenergic blocking agent (Fig. 14). During propranolol-mediated P-receptor block, the chronotropic, ionotropic, and vasodilator responses to P-adrenergic stimulation are decreased.

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Burger's Medicinal Chemistry and Drug Discovery, Cardiovascular Agents and Endocrines by Donald A. Abraham


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