By Frank I. Marcus, Andrea Nava, Gaetano Thiene
This publication covers all facets (biological, pathological, genetics, medical and therapeutical) of arrhythmogenic correct ventricular cardiomyopathy/dysplasia, a contemporary cardiomyopathy which represents a truly excessive probability of unexpected dying within the younger and in athletes. The monograph offers the result of 5-year study application on ARVC/D supported through delivers of either the ecu fee and the NIH, which enabled the invention of seven disease-causing genes, therefore commencing new avenues for the early id of affected sufferers and for surprising loss of life prevention. A panel of most sensible scientists, either ecu and americans, contributed to this quantity, to be able to be a vital reference for execs and citizens in cardiology, radiology, human genetics, and game drugs.
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Extra resources for Arrhythmogenic right ventricular cardiomyopathy dysplasia: Recent Advances
Ventricular arrhythmias were recorded in 12 subjects (46%), ranging from ventricular fibrillation to monomorphic sustained VT with left bundle branch block morphology to nonsustained VT and isolated monomorphic premature ventricular complexes (PVCs). Abnormal echocardiographic findings were present in 14 (54%) DSP mutations carriers, with right ventricular involvement in 13 and left ventricular involvement in seven patients. Eight patients were treated with antiarrhythmic drugs and two received an implantable cardioverter defibrillator (ICD).
Rev Esp Cardiol 53:1296-1300 39. Wichter T, Schulze-Bar E, Eckardt L et al (2002) Molecular mechanisms of inherited ventricular arrhythmias. Hertz 27:712-739 CHAPTER 3 GENOTYPE-PHENOTYPE CORRELATIONS Barbara Bauce, Andrea Nava Introduction The recent genetic discoveries in arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) permit genotype-phenotype correlation in an increasing number of subjects, providing better knowledge of the diagnostic criteria, natural history, and ethiopathogenesis of the disease.
Circulation 97:2049-2058 23. Protonotarios N, Tsatsopoulou A, Anastasakis A et al (2001) Genotype-phenotype assessment in autosomal recessive arrhythmogenic right ventricular cardiomyopathy (Naxos disease) caused by a deletion in plakoglobin. J Am Coll Cardiol 38:1477-1484 24. Protonotarios N, Tsatsopoulou A, Gatzoulis K (2002) Arrhythmogenic right ventricular cardiomyopathy caused by a deletion in plakoglobin (Naxos disease). Card Electrophysiol Rev 6:72-80 25. Basso C, Tsatsopoulou A, Thiene G et al (2001) “Petrified” right ventricle in long-standing Naxos arrhythmogenic right ventricular cardiomyopathy.
Arrhythmogenic right ventricular cardiomyopathy dysplasia: Recent Advances by Frank I. Marcus, Andrea Nava, Gaetano Thiene