Read e-book online Antigen Presenting Cells: From Mechanisms to Drug PDF

By Harald Kropshofer, Anne B. Vogt

ISBN-10: 3527311084

ISBN-13: 9783527311088

This novel, multidisciplinary guide highlights contemporary facts that antigen offering cells (APCs) are usually not purely key avid gamers within the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune reaction, but in addition serious regulators and integrators within the interaction among our innate and adaptive immune system.Structured in a transparent technique to permit entry to a truly extensive readership, the ebook is written from the perspective of a biochemist, immunologist, and scientist with event in drug improvement. It covers all cellphone kinds all in favour of antigen presentation, offering the most recent immunological proof with a spotlight on drug improvement. subsidized by way of a thesaurus explaining all vital technical phrases, this brief yet finished reference covers uncomplicated introductory features correct as much as info for complicated experts.

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Extra info for Antigen Presenting Cells: From Mechanisms to Drug Development

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Cytosolic chaperones such as TRiC may protect peptides from rapid hydrolysis. The transporter associated with antigen processing (TAP) transports peptides of 8–16 amino acids in an ATP-dependent fashion. Subunits TAP1 and TAP2 undergo conformational changes upon peptide binding, upon ATP binding to the nucleotide binding domains, and upon ATP hydrolysis that is linked to substrate release into the ER lumen. N-terminally extended variants of final MHC-I-binding ligands are subjected to trimming by the ERresident aminopeptidase ERAP1, and potentially also by ERAP2/L-RAP.

Immunity 1999, 11, 453–62. 54 Sloan VS, Cameron P, Porter G, Gammon M, Amaya M, Mellins E, Zaller DM. Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature 1995, 375, 802–806. 55 Kropshofer H, Vogt AB, Moldenhauer G, Hammer J, Blum JS, Hammerling GJ. Editing of the HLA-DR-peptide repertoire by HLA-DM. EMBO J. 1996, 15, 6144–6154. 56 van Ham SM, Gruneberg U, Malcherek G, Broker I, Melms A, Trowsdale J. Human histocompatibility leukocyte antigen (HLA)-DM edits peptides pre- 21 22 1 Some Old and Some New Findings on Antigen Processing and Presentation 57 58 59 60 61 62 63 64 65 66 sented by HLA-DR according to their ligand binding motifs.

71 DiPaolo RJ, Unanue ER. The level of peptide-MHC complex determines the susceptibility to autoimmune diabetes: studies in HEL transgenic mice. Eur. J. Immunol. 2001, 31, 3453–3459. 72 Kanagawa O, Martin SM, Vaupel BA, Carrasco-Marin E, Unanue ER. Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction. Proc. Natl. Acad. Sci. A. 1998, 95, 1721–1724. 73 DiPaolo RJ, Unanue ER. Cutting edge: chemical dominance does not relate to immunodominance: studies of the CD4+ T cell response to a model antigen.

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Antigen Presenting Cells: From Mechanisms to Drug Development by Harald Kropshofer, Anne B. Vogt

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