By Manfred Zierhut, Hans-Georg Rammensee, Wayne Streilein
Lately the significance of antigen-presenting cells and their impression at the eyes has been elucidated. we've realized that almost each constitution of the attention harbors those cells, but they range of their actions and therefore within the ways that they defend opposed to - or perform - ailments of the attention. Antigen-Presenting Cells and the attention summarizes present wisdom approximately ACPs often, and their position within the eye, particularly.
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Extra resources for Antigen-presenting cells and the eye
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21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. APC Interactions with Cells During ACAID 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 25 Austyn JM, Gordon S. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol 1981; 11:805–815. Hamerman JA, Aderem A. Functional transitions in macrophages during in vivo infection with Mycobacterium bovis Bacillus Calmette-Guerin. J Immunol 2001; 167:2227–2233. Gordon S, Lawson L, Rabinowitz S, Crocker PR, Morris L, Perry VH.
These studies put to rest the idea that ACAID was a deviation towards a Th2 response. A Role for Chemokines in ACAID During ACAID induction, MIP-2-producing F4/80+ APCs appear first in the bloodstream and then in the spleen. MIP-2 is a murine functional analogue of human IL-8. In ACAID, the MIP-2 chemokine is critical to the recruitment of NKT cells and facilitating tolerance induction and was absolutely required for generation of the Ag specific CD8+ Treg cells (23). ACAID also did not occur in mice that were deficient in CXCR2, the high affinity receptor for MIP-2.
Antigen-presenting cells and the eye by Manfred Zierhut, Hans-Georg Rammensee, Wayne Streilein