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By Gaylon S. Campbell

ISBN-10: 0387949372

ISBN-13: 9780387949376

From reports of the 1st edition:
"well prepared . . . prompt as an introductory textual content for undergraduates"   -- AAAS technological know-how Books and Films

"well written and illustrated"   -- Bulletin of the yankee Meteorological Society

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1984) (With permission from Dvorak et al. 1985d) Fig. 38. (be/ow) Isolated human lung mast cell fixed 3 min after sumulation with anti-IgE shows separated granule contents in individual swollen granules and fusion of granules (arrows). Unaltered lipid bodies and granules are present. N, nucleus. OPF, X 14500 39 Fig. 39. Isolated human lung mast cell fixed 20 min after stimulation with anti-IgE shows degranulation channels with lightly dense, altered granule matrix and numerous large, round, dense lipid bodies adjacent to channels.

Fig. 22. Isolated human lung mast cell fixed 3 min after stimulation with anti-IgE shows swollen, fused granules with altered matrix materials surrounded by intermediate filaments. One granule has fused with plasma membrane and is now open to the exterior (arrow). OCUB, X 42500 24 Fig. 23. Isolated human lung mast cell fixed 3 min after stimulation with anti-IgE shows widened spaces between individual scroll lamellae and altered scroll granule matrix in swollen granules (arrowheads). Cationized ferritin stains the cell surface and one empty.

Fusion of channels with the plasma membrane (Fig. 41). Multiple openings between cytoplasmic channels and the plasma membrane were detectable in mast cells as early as 3 min after anti-IgE, and prominently by 5-20 min. Channels that appeared to have narrow openings always contained altered granule material, and while such openings presumably permitted release of histamine and other low molecular weight substances, in most cases they admitted neither cationized ferritin nor agar (Fig. 41). By contrast, degranulation channels devoid of electron-dense altered granule content admitted both of these tracers, indicating that these structures were in free communication with the exterior (Fig.

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An Introduction To Environmental Biophysics by Gaylon S. Campbell

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