By Theodore Peters Jr.
The 1st of its variety, All approximately Albumin summarizes the chemistry, genetics, metabolism, scientific implications, and advertisement facets of albumin. It presents the main up to date sequences, buildings, and compositions of many species, and contains greater than 2000 references.
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Additional info for All About Albumin: Biochemistry, Genetics, and Medical Applications
The second tryptophan of BSA, on the other hand, was predicted to lie interiorly in a hydrophobic environment. d. R a m a n Spectra. Raman spectra, the series of frequency-shifted emissions following laser excitation, have been investigated with BSA. , 1972; Lin and Koenig, 1976). Using 7r --~ 77-*and resonance Raman measurements, Chen and Lord (1976) also identified C-O, C-C, and C-N bonds. Overall, however, this technique has not yet yielded detailed structural information. e. Nuclear Magnetic Resonance.
Bound fatty acid may raise this figure but bound calcium would lower it; see Chapter 3, Sections I,A and II,B). This is actually a little larger than the net charge of - 12 on the total protein of plasma measured by Figge et al. (1991). These authors derived a formula for calculating the pH of plasma from the pO 2, the net strong ion (salt) charges, the inorganic phosphate concentration, and the albumin concentration. They concluded that albumin alone is significant as a net negative protein ion in plasma, accounting for the bulk of the clinically unmeasured anions.
The binding regions are discussed later in Chapter 3. The particular amino acid residues that they place, in the ligand pockets are listed in Table 2-5 and are indicated in Fig. 2-9. The albumin tertiary structure is unusual in that each of its adjacent CysCys pairs is included in a helical segment, whereas their bonds always join Fig. 2-7. Stereoview of heart-shaped structure of HSA derived from X-ray crystallography. The locations of the 17 S-S bonds and the side chain of CySH-34 are shown in red.
All About Albumin: Biochemistry, Genetics, and Medical Applications by Theodore Peters Jr.