By D. Virgil Alfaro III et al.
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Additional info for Age-Related Macular Degeneration
Contrary to early-onset macular degeneration in cynomolgus macaques, rhesus macaques appear to have a nonmendelian inheritance pattern. Francis et al. (169) genotyped a population of rhesus macaques and found that a susceptibility locus in the rhesus homologue of human 10q26 was associated with macular phenotype. These genes contain sequence variants significantly associated with affected status in humans and macaques. As expected, the LOC387715/ARMS2 gene is present in simians only, thus corresponding with development of the macula.
Subretinal Complement Compounds Injection The role of the complement cascade in the formation of drusen and CNV is unquestionable and has been already discussed (122,136,247). Lyzogubov et al. (248) employed different doses of subretinal PEG-8 to create a new model of CNV. PEG-8 is an activator of both the classical and alternative pathways of the complement system. In this model, PEG-8 injection induced activation of the complement cascade and dose-dependent CNV production. Macrophages Macrophages are believed to have a pivotal role in the development of CNV (249,250).
However, 8-month-old mice exposed to HF diets showed greater thickness compared to that of nonexposed counterparts. Since the plasma cholesterol level was significantly higher in mice on HF diets than the controls, the results were consistent with the suspected role of lipids in the pathogenesis of AMD. A year later to (c) 2015 Wolters Kluwer. All Rights Reserved. 18 SECTION 1 ANATOMY, PHYSIOLOGY, AND PATHOLOGY OF THE MACULA Dithmar’s studies, Cousins et al. (25) compared 2-monthold and 16-month-old C57BL/6 mice fed normal and HF diets.
Age-Related Macular Degeneration by D. Virgil Alfaro III et al.