By Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell
The receptor proposal used to be some of the most influential principles in 20th-century medication since it may account for the hugely particular results of gear at the physique. This e-book is the 1st to supply an historic dialogue of its starting place, improvement, gradual attractiveness into pharmacology and next effect on sleek drugs. It additionally considers the social context that prompted the drug receptor's development., creating a helpful contribution to the historical past and figuring out of recent medication.
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Additional info for A Short History of the Drug Receptor Concept (Science, Technology and Medicine in Modern History)
There is enough evidence to show that this caused severe problems for Ehrlich, who remained a devoted laboratory worker. He caught tuberculosis in 1888, resigned and went to Egypt for recovery. 51 He was unemployed and could set up a small laboratory only with the financial help of his fatherin-law. Ehrlich no longer had any patients and had to rely solely on his dyes and animal experimentation. He turned to immunological work. 53 In 1890, only one year later, the period of private science ended when Robert Koch offered his former helper a post as clinical supervisor for scientific studies on tuberculosis at the City Hospital Berlin-Moabit.
70 Ehrlich’s results were far from encouraging as the concentrations of the solutions of the different diphtheria toxins varied markedly. Moreover, the solutions were not stable, but lost their toxicity after a certain period of storage, although the number of antibody-binding units did not change. This meant that the toxic effect did not correspond to the capacity of the toxin to bind to antitoxin. 71 Forced to explain these results, Ehrlich came back to his ‘side-chain theory’. The toxin was thought to consist of two parts: a poisonous component, the so-called ‘toxophore group’ (toxophore Gruppe), and a component which enabled the binding to the antitoxin, the socalled ‘haptophore group’ (haptophore Gruppe).
76 Ehrlich was able to organize and to coordinate experimental studies using numerous assistants. 77 In 1906, after the research on the side-chain or receptor theory had come to a notable conclusion, Morgenroth became head of the department of bacteriology at the pathological institute of the Charité Hospital in Berlin, walking in the footsteps of Ehrlich and performing research on immunology. 78 Morgenroth was very important as a collaborator and he disseminated Ehrlich’s concept at a later stage in his career, contributing most prolifically to the development of the receptor concept compared to other assistants.
A Short History of the Drug Receptor Concept (Science, Technology and Medicine in Modern History) by Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell